Overdose may occur after an acute single ingestion of a large amount of acetaminophen or acetaminophen-containing medication, or repeated ingestion of an amount exceeding recommended dosage.
Patients are often asymptomatic or have only mild gastrointestinal symptoms at initial presentation. Untreated acetaminophen poisoning may cause varying degrees of liver injury over the 1 to 4 days following ingestion, including fulminant hepatic failure.
Rarely, massive overdose may initially present with coma and severe metabolic acidosis. Presentation with coma may also occur if a combination preparation of acetaminophen and opioid is taken in overdose, or after an overdose of multiple drugs.
Acetaminophen Davis Drug Book
Alanine Aminotransferase answers are found in the Davis's Lab & Diagnostic Tests powered by Unbound Medicine. Available for iPhone, iPad, Android, and Web. Asprin redirects here. For the author, see Robert Asprin. Nerve Pain Progression. Nerve pain is often progressive, especially if the root cause (for example, diabetes) is not treated. The usual progression of nerve pain is that it begins far away from the brain and spinal cord (hands and feet) and spreads backwards (retrograde) towards the arms and legs. Rivera-Penera T, Gugig R, Davis J. Outcome of acetaminophen overdose in pediatric patients and factors contributing to hepatotoxicity.
Acetaminophen Davis Drug Card
Hepatotoxicity is extremely rare in patients treated with acetylcysteine within 8 hours of an acute acetaminophen overdose. The efficacy of acetylcysteine decreases subsequent to the first 8 hours following an acute acetaminophen overdose, with a corresponding stepwise increase in hepatotoxicity with increasing treatment delays beyond 8 hours.